Oral Acetyl-L-Carnitine treatment in hepatic encephalopathy: view of evidence-based medicine

Oral acetyl-L-carnitine treatment in hepatic encephalopathy: view of evidence-based medicine.

OBJECTIVE To systematically review the effect of acetyl-L-carnitine in patients with hepatic encephalopathy. MATERIAL AND METHODS DESIGN systematic review and meta-analysis. DATA SOURCES The Cochrane Library, MEDLINE, EMBASE.com, Science Citation Index, Google search and the China Biological Medicine Database to June 2012. REVIEW METHODS randomized placebo controlled trials of acetyl-L...

Pharmacotherapy for Hepatic encephalopathy: view of Evidence-Based Medicine

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Acetyl-L-Carnitine Monograph

Introduction Acetyl-L-carnitine (ALC) is an ester of the trimethylated amino acid, L-carnitine, and is synthesized in the human brain, liver, and kidney by the enzyme ALC-transferase. Acetyl-L-carnitine facilitates the uptake of acetyl CoA into the mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane phospholipid synthesis. ALC, simila...

Oral acetyl-L-carnitine therapy and insulin resistance.

Comparison of pharmacokinetics of L-carnitine, acetyl-L-carnitine and propionyl-L-carnitine after single oral administration of L-carnitine in healthy volunteers.

PURPOSE To investigate the pharmacokinetics of L-carnitine (LC) and its analogues, acetyl-L-carnitine (ALC) and propionyl-L-carnitine (PLC) in healthy volunteers after single L-carnitine administration. METHODS Liquid L-carnitine (2.0 g) was administered orally as a single dose in 12 healthy subjects. Plasma and urine concentrations of L-carnitine, ALC and PLC were detected by HPLC. RESULTS...